Dysplastic nevus - Düsplastiline Nevus
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Dysplastic nevi ― Biopsia on soovitatav läänlastele.
relevance score : -100.0%
ReferencesDysplastic nevus, tuntud ka kui ebatüüpiline või Clarksi nevus, on tekitanud arutelusid dermatoloogias ja dermatopatoloogias. Arstid teevad sageli nende muttide biopsiat, kuna need võivad välja näha ebanormaalseid ja tekitada muret melanoomi pärast.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, tuntud ka kui ebatüüpiline või Clarki nevus, võivad mõnikord põhjustada melanoomi. Umbes 36 % melanoomidest leitakse düsplastiliste nevude lähedusest. Märgid, mis viitavad sellele, et düsplastiline nevus võib muutuda melanoomiks, on ebaühtlane kuju, rohkem pigmendimuutusi või hallikas värvus. Need vähi- või muutused tekivad tavaliselt nooremas eas (umbes kolmekümnendate aastate keskel), võivad esineda mitmel korral ja ilmnevad sageli kehatüvel. Geneetiliselt on dysplastic nevi healoomulise nevi ja melanoomi vahepealne. Kuid ainult 20–30 % melanoomidest pärinevad olemasolevatest nevustest. Kuna enamik nevudest ei muutu melanoomiks, ei ole tavaliselt soovitatav neid ennetavalt eemaldada.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoom on teatud tüüpi kasvaja, mis tekib siis, kui melanotsüüdid – nahavärvi eest vastutavad rakud – muutuvad vähirakkudeks. Melanotsüüdid pärinevad närviharjast. Seetõttu võivad melanoomid areneda mitte ainult nahal, vaid ka muudes piirkondades, kus närvirakud migreeruvad, näiteks seedetraktis ja ajus. Varajases staadiumis (I staadium) diagnoositud melanoomiga patsientide elulemus on kõrge – umbes 97 %. Kaugearenenud staadiumis (IV staadium) diagnoositud patsientide elulemus langeb märkimisväärselt, ligikaudu 10 %.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ vähirisk
Nagu Ameerika Ühendriikide kaukaasia indiviididel on näha, on düsplastilise neviga inimestel eluaegne risk melanoomi tekkeks üle 10 %. Teisest küljest on neil, kellel puudub düsplastiline nevus, melanoomi tekkerisk alla 1 %.
○ Ettevaatusabinõud düsplastilise neviga inimestele
Naha eneseanalüüsi soovitatakse tavaliselt melanoomi ennetamiseks (ebatüüpiliste nevi tuvastamise teel) või olemasolevate kasvajate varajaseks avastamiseks. Inimesed, kellel on isiklikult või perekonnas esinenud nahavähki või mitut ebatüüpilist nevi, peaksid külastama dermatoloogi vähemalt kord aastas, et olla kindel, et neil ei tekiks melanoomi.
Lühend [ABCDE] on olnud kasulik, et aidata tervishoiuteenuse osutajatel ja võõrkohtadel meeles pidada melanoomi põhiomadusi. Kahjuks võivad paljudel seborroilistel keratoosidel, mõnel seniilsel lentiigosel ja isegi tüükadel olla [ABCDE] tunnused, mida ei saa melanoomist eristada.
○ [ABCDE]
Asymmetrical: Asümmeetriline nahakahjustus.
Border: Kahjustuse piir on ebakorrapärane.
Color: melanoomidel on tavaliselt mitu ebakorrapärast värvi.
Diameter: Nevi, mille läbimõõt on üle 6 mm, on tõenäolisemalt melanoomid kui väiksemad.
Evolution: Nevuse või kahjustuse areng (st muutus) võib viidata sellele, et kahjustus on muutumas pahaloomuliseks.